Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q9HCJ2
UPID:
LRC4C_HUMAN
Alternative names:
Netrin-G1 ligand
Alternative UPACC:
Q9HCJ2; A8K0T1; Q7L0N3
Background:
Leucine-rich repeat-containing protein 4C, also known as Netrin-G1 ligand, plays a crucial role in the development of the nervous system. Its primary function is to promote neurite outgrowth of developing thalamic neurons, which is essential for the formation of neural networks during early brain development.
Therapeutic significance:
Understanding the role of Leucine-rich repeat-containing protein 4C could open doors to potential therapeutic strategies. Its involvement in neural development positions it as a key target for research into neurological disorders and regenerative medicine.