Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q9HCJ2
UPID:
LRC4C_HUMAN
Alternative names:
Netrin-G1 ligand
Alternative UPACC:
Q9HCJ2; A8K0T1; Q7L0N3
Background:
Leucine-rich repeat-containing protein 4C, also known as Netrin-G1 ligand, plays a crucial role in the development of the nervous system. Its primary function is to promote neurite outgrowth of developing thalamic neurons, which is essential for the formation of neural networks during early brain development.
Therapeutic significance:
Understanding the role of Leucine-rich repeat-containing protein 4C could open doors to potential therapeutic strategies. Its involvement in neural development positions it as a key target for research into neurological disorders and regenerative medicine.