Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We employ our advanced, specialised process to create targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
This approach involves comprehensive molecular simulations of the catalytic and allosteric binding pockets and ensemble virtual screening that accounts for their conformational flexibility. In the case of designing modulators, the structural adjustments caused by reaction intermediates are considered to improve activity and selectivity.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q9HCP0
UPID:
KC1G1_HUMAN
Alternative names:
-
Alternative UPACC:
Q9HCP0; Q5JPH1; Q96AE9; Q9HCP1
Background:
Casein kinase I isoform gamma-1, encoded by the gene with accession number Q9HCP0, is a serine/threonine-protein kinase. It is known for its role in phosphorylating a wide array of proteins, showcasing its versatility in cellular processes. This kinase is a key player in the Wnt signaling pathway and is crucial for regulating synaptic transmission mediated by glutamate, highlighting its importance in neural communication.
Therapeutic significance:
Understanding the role of Casein kinase I isoform gamma-1 could open doors to potential therapeutic strategies. Its involvement in critical signaling pathways and neural communication underscores its potential as a target for drug discovery, aiming to modulate its activity for therapeutic benefits.