Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
Our top-notch dedicated system is used to design specialised libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The procedure entails thorough molecular simulations of the catalytic and allosteric binding pockets, accompanied by ensemble virtual screening that factors in their conformational flexibility. When developing modulators, the structural modifications brought about by reaction intermediates are factored in to optimize activity and selectivity.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q9NP78
UPID:
ABCB9_HUMAN
Alternative names:
ATP-binding cassette sub-family B member 9; ATP-binding cassette transporter 9; TAP-like protein
Alternative UPACC:
Q9NP78; B4E2J0; Q5W9G7; Q769F3; Q769F4; Q96AB1; Q9P208
Background:
The ABC-type oligopeptide transporter ABCB9, also known as ATP-binding cassette sub-family B member 9, plays a crucial role in cellular processes by transporting a wide range of peptides from the cytosol to the lysosomal lumen for degradation. It has a broad peptide length specificity, efficiently translocating peptides ranging from 6 to at least 59 amino acids, with an optimal length of 23 amino acids. ABCB9 shows a preference for peptides with positively charged, aromatic, or hydrophobic residues at their termini.
Therapeutic significance:
Understanding the role of ABCB9 could open doors to potential therapeutic strategies.