Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We utilise our cutting-edge, exclusive workflow to develop focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The procedure entails thorough molecular simulations of the catalytic and allosteric binding pockets, accompanied by ensemble virtual screening that factors in their conformational flexibility. When developing modulators, the structural modifications brought about by reaction intermediates are factored in to optimize activity and selectivity.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q9NPA2
UPID:
MMP25_HUMAN
Alternative names:
Leukolysin; Membrane-type matrix metalloproteinase 6; Membrane-type-6 matrix metalloproteinase
Alternative UPACC:
Q9NPA2; D3DUA8; Q9H3Q0
Background:
Matrix metalloproteinase-25, also known as Leukolysin, Membrane-type matrix metalloproteinase 6, and Membrane-type-6 matrix metalloproteinase, plays a crucial role in the activation of progelatinase A. Its unique enzymatic activity is pivotal in the breakdown of the extracellular matrix, a fundamental process in cellular proliferation, migration, differentiation, and remodeling.
Therapeutic significance:
Understanding the role of Matrix metalloproteinase-25 could open doors to potential therapeutic strategies. Its involvement in the regulation of the extracellular matrix presents a promising target for the development of novel treatments aimed at controlling tissue remodeling and disease progression.