Focused On-demand Library for Lysophosphatidic acid phosphatase type 6

Available from Reaxense
Predicted by Alphafold

Focused On-demand Libraries - Reaxense Collaboration

Explore the Potential with AI-Driven Innovation

This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.

We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.

Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.

Our high-tech, dedicated method is applied to construct targeted libraries for enzymes.

 Fig. 1. The sreening workflow of Receptor.AI

The method includes detailed molecular simulations of the catalytic and allosteric binding pockets, along with ensemble virtual screening that considers their conformational flexibility. In the design of modulators, structural changes induced by reaction intermediates are taken into account to enhance activity and selectivity.

Our library is unique due to several crucial aspects:

  • Receptor.AI compiles all relevant data on the target protein, such as past experimental results, literature findings, known ligands, and structural data, thereby enhancing the likelihood of focusing on the most significant compounds.
  • By utilizing advanced molecular simulations, the platform is adept at locating potential binding sites, rendering the compounds in the focused library well-suited for unearthing allosteric inhibitors and binders for hidden pockets.
  • The platform is supported by more than 50 highly specialized AI models, all of which have been rigorously tested and validated in diverse drug discovery and research programs. Its design emphasizes efficiency, reliability, and accuracy, crucial for producing focused libraries.
  • Receptor.AI extends beyond just creating focused libraries; it offers a complete spectrum of services and solutions during the preclinical drug discovery phase, with a success-dependent pricing strategy that reduces risk and fosters shared success in the project.







Alternative names:

Acid phosphatase 6, lysophosphatidic; Acid phosphatase-like protein 1; PACPL1

Alternative UPACC:

Q9NPH0; Q59G61; Q5T490; Q6IAQ3; Q7LG81; Q9UIG6; X5D289


Lysophosphatidic acid phosphatase type 6, known as Acid phosphatase 6, lysophosphatidic or PACPL1, plays a crucial role in lipid metabolism. It specifically hydrolyzes lysophosphatidic acid (LPA) with medium length fatty acid chains into monoacylglycerol, showing highest activity with myristate (C14:0), oleate (C18:1), and palmitate (C16:0).

Therapeutic significance:

Understanding the role of Lysophosphatidic acid phosphatase type 6 could open doors to potential therapeutic strategies. Its involvement in lipid metabolism suggests its potential impact on diseases related to lipid dysregulation.

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