Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We employ our advanced, specialised process to create targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
This approach involves comprehensive molecular simulations of the catalytic and allosteric binding pockets and ensemble virtual screening that accounts for their conformational flexibility. In the case of designing modulators, the structural adjustments caused by reaction intermediates are considered to improve activity and selectivity.
Key features that set our library apart include:
partner
Reaxense
upacc
Q9NQV8
UPID:
PRDM8_HUMAN
Alternative names:
PR domain-containing protein 8
Alternative UPACC:
Q9NQV8; A8K7X2; Q6IQ36
Background:
PR domain zinc finger protein 8, alternatively known as PR domain-containing protein 8, plays a crucial role in various biological processes. It acts as a probable histone methyltransferase, targeting 'Lys-9' of histone H3, and is involved in transcriptional repression of steroidogenesis marker genes such as CYP17A1 and LHCGR. Additionally, it forms a complex with BHLHE22 to control genes essential for neural development and neuronal differentiation. In the retina, it is vital for the survival of rod bipolar and type 2 OFF-cone bipolar cells.
Therapeutic significance:
The protein's association with Epilepsy, progressive myoclonic 10, a disorder characterized by a spectrum of symptoms including myoclonus, ataxia, and cognitive decline, underscores its therapeutic significance. Understanding the role of PR domain zinc finger protein 8 could open doors to potential therapeutic strategies for this and related neurological conditions.