Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
Our high-tech, dedicated method is applied to construct targeted libraries for protein-protein interfaces.
Fig. 1. The sreening workflow of Receptor.AI
This process entails comprehensive molecular simulations of the target protein, individually and in complex with essential partner proteins, along with ensemble virtual screening that focuses on conformational mobility in both its free and complex states. Potential binding pockets are considered at the protein-protein interaction interface and in remote allosteric locations to address every conceivable mechanism of action.
Key features that set our library apart include:
partner
Reaxense
upacc
Q9NR28
UPID:
DBLOH_HUMAN
Alternative names:
Diablo homolog, mitochondrial; Direct IAP-binding protein with low pI; Second mitochondria-derived activator of caspase
Alternative UPACC:
Q9NR28; B2RDQ0; Q6W3F3; Q96LV0; Q9BT11; Q9HAV6
Background:
Diablo IAP-binding mitochondrial protein, also known as Diablo homolog, mitochondrial, Direct IAP-binding protein with low pI, and Second mitochondria-derived activator of caspase, plays a pivotal role in promoting apoptosis. It activates caspases in the cytochrome c/Apaf-1/caspase-9 pathway, countering the inhibitory activity of IAPs and facilitating the degradation of XIAP/BIRC4 through the ubiquitin-proteasome pathway.
Therapeutic significance:
Linked to Deafness, autosomal dominant, 64, due to its role in apoptosis, understanding Diablo IAP-binding mitochondrial protein's function could unveil new therapeutic strategies for sensorineural hearing loss and potentially other apoptosis-related disorders.