Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
Q9NRP0
UPID:
OSTC_HUMAN
Alternative names:
Hydrophobic protein HSF-28
Alternative UPACC:
Q9NRP0; A8MYS2; B2R5H1; D6RH22; Q9P075; Q9P1R4
Background:
The Oligosaccharyltransferase complex subunit OSTC, also known as Hydrophobic protein HSF-28, plays a pivotal role in protein N-glycosylation. This process involves the transfer of a glycan from dolichol-pyrophosphate to an asparagine residue within nascent polypeptide chains, a crucial step in protein maturation and function. The OSTC is part of the STT3A-containing form of the oligosaccharyl transferase complex, closely associated with the Sec61 complex at the ER translocon, facilitating protein translocation across the endoplasmic reticulum.
Therapeutic significance:
Understanding the role of Oligosaccharyltransferase complex subunit OSTC could open doors to potential therapeutic strategies.