Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our top-notch dedicated system is used to design specialised libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
This approach involves comprehensive molecular simulations of the catalytic and allosteric binding pockets and ensemble virtual screening that accounts for their conformational flexibility. In the case of designing modulators, the structural adjustments caused by reaction intermediates are considered to improve activity and selectivity.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q9NRS4
UPID:
TMPS4_HUMAN
Alternative names:
Channel-activating protease 2; Membrane-type serine protease 2
Alternative UPACC:
Q9NRS4; A8MU84; B0YJB0; B7Z8C5; E7ERX8; Q5XKQ6; Q6UX37; Q9NZA5
Background:
Transmembrane protease serine 4, also known as Channel-activating protease 2 or Membrane-type serine protease 2, is a plasma membrane-anchored serine protease. It plays a crucial role in the activation of pro-uPA/PLAU into its active form through proteolytic activity, as well as potentially activating ENaC. Furthermore, it facilitates SARS-CoV-2 infection in gut epithelial cells by cleaving coronavirus spike glycoproteins, enabling host cell entry.
Therapeutic significance:
Understanding the role of Transmembrane protease serine 4 could open doors to potential therapeutic strategies, especially in the context of viral infections such as SARS-CoV-2.