Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We use our state-of-the-art dedicated workflow for designing focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The procedure entails thorough molecular simulations of the catalytic and allosteric binding pockets, accompanied by ensemble virtual screening that factors in their conformational flexibility. When developing modulators, the structural modifications brought about by reaction intermediates are factored in to optimize activity and selectivity.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q9NVM4
UPID:
ANM7_HUMAN
Alternative names:
Histone-arginine N-methyltransferase PRMT7; [Myelin basic protein]-arginine N-methyltransferase PRMT7
Alternative UPACC:
Q9NVM4; B3KPR0; B3KUG9; B4E379; Q96PV5; Q9H9L0
Background:
Protein arginine N-methyltransferase 7 (PRMT7) is known for its critical role in arginine methylation, impacting various biological processes. It catalyzes the formation of omega-N monomethylarginine and symmetrical dimethylarginine, with a preference for the former. PRMT7's activity is essential for the methylation of specific proteins, including histones and myelin basic protein, influencing snRNP core particle assembly, gene imprinting, and possibly embryonic stem cell pluripotency.
Therapeutic significance:
The involvement of PRMT7 in a rare autosomal recessive disease characterized by developmental delay, learning disabilities, and skeletal abnormalities highlights its potential as a therapeutic target. Understanding the role of PRMT7 could open doors to potential therapeutic strategies for treating this condition and possibly other related disorders.