Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q9NVS2
UPID:
RT18A_HUMAN
Alternative names:
39S ribosomal protein S18-3, mitochondrial; 39S ribosomal protein S18a, mitochondrial; Large ribosomal subunit protein bS18a
Alternative UPACC:
Q9NVS2; A6XND3; Q5QPA4
Background:
The Large ribosomal subunit protein mL66, also known as 39S ribosomal protein S18-3, mitochondrial, 39S ribosomal protein S18a, mitochondrial, and Large ribosomal subunit protein bS18a, plays a crucial role in the mitochondrial ribosome. Its primary function is to ensure the proper assembly and functioning of the ribosome, which is essential for protein synthesis within the cell.
Therapeutic significance:
Understanding the role of Large ribosomal subunit protein mL66 could open doors to potential therapeutic strategies. Its pivotal role in protein synthesis makes it an intriguing target for research aimed at addressing mitochondrial diseases and disorders related to protein synthesis.