Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We utilise our cutting-edge, exclusive workflow to develop focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
This approach involves comprehensive molecular simulations of the catalytic and allosteric binding pockets and ensemble virtual screening that accounts for their conformational flexibility. In the case of designing modulators, the structural adjustments caused by reaction intermediates are considered to improve activity and selectivity.
Key features that set our library apart include:
partner
Reaxense
upacc
Q9NWZ5
UPID:
UCKL1_HUMAN
Alternative names:
-
Alternative UPACC:
Q9NWZ5; B7Z8N2; Q5JWV0; Q70AQ5; Q8N524; Q9H3Z2
Background:
Uridine-cytidine kinase-like 1 plays a crucial role in nucleotide metabolism, facilitating the conversion processes essential for cellular functions. Its involvement in UTP accumulation underscores its importance in cellular proliferation and transformation, pivotal for both normal and pathological states.
Therapeutic significance:
Understanding the role of Uridine-cytidine kinase-like 1 could open doors to potential therapeutic strategies. Its fundamental contribution to nucleotide metabolism presents a unique opportunity for targeting in diseases where cellular proliferation is dysregulated.