Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We utilise our cutting-edge, exclusive workflow to develop focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The method includes detailed molecular simulations of the catalytic and allosteric binding pockets, along with ensemble virtual screening that considers their conformational flexibility. In the design of modulators, structural changes induced by reaction intermediates are taken into account to enhance activity and selectivity.
Key features that set our library apart include:
partner
Reaxense
upacc
Q9NXF8
UPID:
ZDHC7_HUMAN
Alternative names:
Acyltransferase ZDHHC7; Zinc finger DHHC domain-containing protein 7
Alternative UPACC:
Q9NXF8; D3DUM1; Q8WV42; Q9NVD8
Background:
Palmitoyltransferase ZDHHC7, also known as Acyltransferase ZDHHC7 and Zinc finger DHHC domain-containing protein 7, is a versatile enzyme localized in the Golgi apparatus. It catalyzes the addition of palmitate and other fatty acids onto various protein substrates, impacting numerous biological processes. This protein is involved in the regulation of sex steroid hormone receptors, G protein-coupled receptor signaling via GNAQ, the FAS signaling pathway, cell polarity and differentiation through SCRIB, cell migration via JAM3, and the insulin-dependent translocation of GLUT4.
Therapeutic significance:
Understanding the role of Palmitoyltransferase ZDHHC7 could open doors to potential therapeutic strategies.