Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
Our top-notch dedicated system is used to design specialised libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
This approach involves comprehensive molecular simulations of the catalytic and allosteric binding pockets and ensemble virtual screening that accounts for their conformational flexibility. In the case of designing modulators, the structural adjustments caused by reaction intermediates are considered to improve activity and selectivity.
Key features that set our library apart include:
partner
Reaxense
upacc
Q9NZ08
UPID:
ERAP1_HUMAN
Alternative names:
ARTS-1; Adipocyte-derived leucine aminopeptidase; Aminopeptidase PILS; Puromycin-insensitive leucyl-specific aminopeptidase; Type 1 tumor necrosis factor receptor shedding aminopeptidase regulator
Alternative UPACC:
Q9NZ08; O60278; Q6UWY6; Q8NEL4; Q8TAD0; Q9UHF8; Q9UKY2
Background:
Endoplasmic reticulum aminopeptidase 1 (ERAP1), known by alternative names such as ARTS-1 and Adipocyte-derived leucine aminopeptidase, plays a pivotal role in peptide trimming for HLA class I-binding peptides presentation. It specializes in processing substrates 9-16 residues long, favoring those with a hydrophobic C-terminus, and is crucial in regulating blood pressure via angiotensin II inactivation.
Therapeutic significance:
Understanding the role of Endoplasmic reticulum aminopeptidase 1 could open doors to potential therapeutic strategies, especially in the context of immune response modulation and hypertension management.