Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our high-tech, dedicated method is applied to construct targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
This approach involves comprehensive molecular simulations of the catalytic and allosteric binding pockets and ensemble virtual screening that accounts for their conformational flexibility. In the case of designing modulators, the structural adjustments caused by reaction intermediates are considered to improve activity and selectivity.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q9P0G3
UPID:
KLK14_HUMAN
Alternative names:
Kallikrein-like protein 6
Alternative UPACC:
Q9P0G3; A7UNK5; Q1RMZ2; Q6B089
Background:
Kallikrein-14, also known as Kallikrein-like protein 6, is a serine-type endopeptidase exhibiting dual trypsin-like and chymotrypsin-like substrate specificity. It plays a pivotal role in various physiological processes, including seminal clot liquefaction by cleaving semenogelin SEMG1 and SEMG2, and facilitating epidermal desquamation through desmoglein DSG1 cleavage. Its activity extends to the activation of proteinase-activated receptors and other kallikreins, contributing to tumor progression dynamics such as growth, invasion, and angiogenesis.
Therapeutic significance:
Understanding the role of Kallikrein-14 could open doors to potential therapeutic strategies, particularly in addressing its involvement in tumor progression and reproductive health.