Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q9P0L9
UPID:
PK2L1_HUMAN
Alternative names:
Polycystic kidney disease 2-like 1 protein; Polycystin-2 homolog; Polycystin-L; Polycystin-L1
Alternative UPACC:
Q9P0L9; O75972; Q5W039; Q9UP35; Q9UPA2
Background:
Polycystin-2-like protein 1, also known as Polycystic kidney disease 2-like 1 protein, plays a crucial role in various physiological processes. It functions as a pore-forming subunit of a heterotetrameric, non-selective cation channel, permeable to Ca(2+), essential for maintaining calcium homeostasis. This protein is involved in forming calcium-permeant ion channels in primary cilia, regulating sonic hedgehog/SHH signaling and GLI2 transcription, crucial for developmental processes. Additionally, it contributes to sour taste perception and potentially the perception of carbonation taste.
Therapeutic significance:
Understanding the role of Polycystin-2-like protein 1 could open doors to potential therapeutic strategies.