Focused On-demand Library for Teneurin-3

Available from Reaxense
Predicted by Alphafold

Focused On-demand Libraries - Reaxense Collaboration

Explore the Potential with AI-Driven Innovation

The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.

Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.

The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.

Our top-notch dedicated system is used to design specialised libraries.

 Fig. 1. The sreening workflow of Receptor.AI

Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.

Our library is unique due to several crucial aspects:

  • Receptor.AI compiles all relevant data on the target protein, such as past experimental results, literature findings, known ligands, and structural data, thereby enhancing the likelihood of focusing on the most significant compounds.
  • By utilizing advanced molecular simulations, the platform is adept at locating potential binding sites, rendering the compounds in the focused library well-suited for unearthing allosteric inhibitors and binders for hidden pockets.
  • The platform is supported by more than 50 highly specialized AI models, all of which have been rigorously tested and validated in diverse drug discovery and research programs. Its design emphasizes efficiency, reliability, and accuracy, crucial for producing focused libraries.
  • Receptor.AI extends beyond just creating focused libraries; it offers a complete spectrum of services and solutions during the preclinical drug discovery phase, with a success-dependent pricing strategy that reduces risk and fosters shared success in the project.







Alternative names:

Protein Odd Oz/ten-m homolog 3; Tenascin-M3; Teneurin transmembrane protein 3

Alternative UPACC:

Q9P273; Q5XUL9; Q96SY2; Q9NV77; Q9NVW1; Q9NZJ2


Teneurin-3, also known as Protein Odd Oz/ten-m homolog 3, Tenascin-M3, and Teneurin transmembrane protein 3, plays a pivotal role in neural development. It regulates the establishment of proper connectivity within the nervous system, influencing both pre- and postsynaptic neurons in the hippocampus for precise topographic projection. Its involvement extends to proper dendrite morphogenesis and axon targeting in the visual system, crucial for the development of the visual pathway.

Therapeutic significance:

Teneurin-3's association with Microphthalmia, isolated, with coloboma, 9, and Microphthalmia, syndromic, 15, underscores its therapeutic potential. Understanding the role of Teneurin-3 could open doors to potential therapeutic strategies for these ocular disorders, highlighting the importance of further research into its functions and mechanisms.

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