Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
Our top-notch dedicated system is used to design specialised libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
This approach involves comprehensive molecular simulations of the catalytic and allosteric binding pockets and ensemble virtual screening that accounts for their conformational flexibility. In the case of designing modulators, the structural adjustments caused by reaction intermediates are considered to improve activity and selectivity.
Key features that set our library apart include:
partner
Reaxense
upacc
Q9P286
UPID:
PAK5_HUMAN
Alternative names:
p21-activated kinase 5; p21-activated kinase 7
Alternative UPACC:
Q9P286; A8K5T6; D3DW14; Q5W115; Q8TB93; Q9BX09; Q9ULF6
Background:
Serine/threonine-protein kinase PAK 5, also known as p21-activated kinase 5 and 7, is a pivotal enzyme in signaling pathways that govern cell migration, proliferation, and survival. It is activated by growth factor receptors or CDC42 and RAC1, leading to autophosphorylation on serine/threonine residues. This kinase not only phosphorylates RAF1 to stimulate its activity but also promotes cell survival by phosphorylating BAD. Additionally, it plays a role in cytoskeletal organization by phosphorylating CTNND1 and regulating microtubule stability.
Therapeutic significance:
Understanding the role of Serine/threonine-protein kinase PAK 5 could open doors to potential therapeutic strategies.