Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q9P2R6
UPID:
RERE_HUMAN
Alternative names:
Atrophin-1-like protein; Atrophin-1-related protein
Alternative UPACC:
Q9P2R6; O43393; O75046; O75359; Q5VXL9; Q6P6B9; Q9Y2W4
Background:
The Arginine-glutamic acid dipeptide repeats protein, also known as Atrophin-1-like protein or Atrophin-1-related protein, plays a pivotal role in cellular processes. It functions as a transcriptional repressor during development and is involved in cell survival regulation. Its overexpression leads to the recruitment of BAX to the nucleus, triggering caspase-3 activation and cell death.
Therapeutic significance:
Linked to a neurodevelopmental disorder with potential brain, eye, or heart anomalies, understanding the role of Arginine-glutamic acid dipeptide repeats protein could open doors to potential therapeutic strategies. Its involvement in transcriptional repression and cell survival pathways offers a promising avenue for targeted interventions in related diseases.