Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We utilise our cutting-edge, exclusive workflow to develop focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
This approach involves comprehensive molecular simulations of the catalytic and allosteric binding pockets and ensemble virtual screening that accounts for their conformational flexibility. In the case of designing modulators, the structural adjustments caused by reaction intermediates are considered to improve activity and selectivity.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q9UBG3
UPID:
CRNN_HUMAN
Alternative names:
53 kDa putative calcium-binding protein; 53 kDa squamous epithelial-induced stress protein; 58 kDa heat shock protein; Squamous epithelial heat shock protein 53; Tumor-related protein
Alternative UPACC:
Q9UBG3; B2RE60; Q8N613
Background:
Cornulin, also known as a 53 kDa putative calcium-binding protein, plays a crucial role in promoting cell proliferation and G1/S cell cycle progression. It is instrumental in regulating the pro-inflammatory cytokine response through activation of NFKB1 and PI3K/AKT signaling pathways. This protein's involvement in cellular stress responses, particularly in squamous epithelial cells, underscores its biological significance.
Therapeutic significance:
Given its association with esophageal cancer, understanding Cornulin's function could pave the way for innovative therapeutic approaches. Its role in cell proliferation and cycle progression, coupled with disease susceptibility linked to gene variants, highlights its potential as a target for cancer treatment strategies.