Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q9UBU9
UPID:
NXF1_HUMAN
Alternative names:
Tip-associated protein; Tip-associating protein; mRNA export factor TAP
Alternative UPACC:
Q9UBU9; B4E269; Q99799; Q9UQL2
Background:
Nuclear RNA export factor 1, also known as NXF1, plays a crucial role in the nuclear export of mRNA species bearing retroviral constitutive transport elements and in the export of mRNA from the nucleus to the cytoplasm via the TAP/NFX1 pathway. It forms a heterodimer with NXT1, facilitating the export of HSP70 mRNA in collaboration with components of the TREX complex. Additionally, NXF1 is involved in the nuclear export of m6A-containing mRNAs, highlighting its significance in mRNA processing and transport.
Therapeutic significance:
Understanding the role of Nuclear RNA export factor 1 could open doors to potential therapeutic strategies.