Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q9UBW7
UPID:
ZMYM2_HUMAN
Alternative names:
Fused in myeloproliferative disorders protein; Rearranged in atypical myeloproliferative disorder protein; Zinc finger protein 198
Alternative UPACC:
Q9UBW7; A6NDG0; A6NI02; O43212; O43434; O60898; Q5W0Q4; Q5W0T3; Q63HP0; Q8NE39; Q9H0V5; Q9H538; Q9UEU2
Background:
Zinc finger MYM-type protein 2, also known as Fused in myeloproliferative disorders protein, plays a crucial role in the negative regulation of transcription. Its alternative names include Rearranged in atypical myeloproliferative disorder protein and Zinc finger protein 198, highlighting its significance in gene expression modulation.
Therapeutic significance:
This protein is linked to Neurodevelopmental-craniofacial syndrome with variable renal and cardiac abnormalities, a disorder marked by craniofacial anomalies, developmental delays, and potential renal and cardiac defects. Understanding the role of Zinc finger MYM-type protein 2 could open doors to potential therapeutic strategies for this syndrome.