Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q9UG63
UPID:
ABCF2_HUMAN
Alternative names:
Iron-inhibited ABC transporter 2
Alternative UPACC:
Q9UG63; O60864; Q75MJ0; Q75MJ1; Q96TE8
Background:
ATP-binding cassette sub-family F member 2, also known as Iron-inhibited ABC transporter 2, plays a crucial role in cellular processes by facilitating the transport of various molecules across extracellular and intracellular membranes. Its unique mechanism, driven by ATP hydrolysis, positions it as a key player in the maintenance of cellular homeostasis.
Therapeutic significance:
Understanding the role of ATP-binding cassette sub-family F member 2 could open doors to potential therapeutic strategies. Its involvement in critical transport functions suggests that modulation of its activity could have significant implications for disease treatment and drug delivery.