Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
Our top-notch dedicated system is used to design specialised libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The method includes detailed molecular simulations of the catalytic and allosteric binding pockets, along with ensemble virtual screening that considers their conformational flexibility. In the design of modulators, structural changes induced by reaction intermediates are taken into account to enhance activity and selectivity.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q9UGB7
UPID:
MIOX_HUMAN
Alternative names:
Aldehyde reductase-like 6; Kidney-specific protein 32; Myo-inositol oxygenase; Renal-specific oxidoreductase
Alternative UPACC:
Q9UGB7; Q05DJ6; Q5S8C9; Q9BZZ1; Q9UHB8
Background:
Inositol oxygenase, also known by alternative names such as Aldehyde reductase-like 6, Kidney-specific protein 32, Myo-inositol oxygenase, and Renal-specific oxidoreductase, plays a pivotal role in cellular metabolism. This enzyme is crucial for the conversion of myo-inositol into D-glucuronic acid, a process integral to the proper functioning of renal and other tissues.
Therapeutic significance:
Understanding the role of Inositol oxygenase could open doors to potential therapeutic strategies. Its critical function in cellular metabolism highlights its potential as a target for addressing metabolic disorders and renal diseases.