Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q9UHR6
UPID:
ZNHI2_HUMAN
Alternative names:
Protein FON
Alternative UPACC:
Q9UHR6; Q3SY14; Q8IUV0
Background:
Zinc finger HIT domain-containing protein 2, also known as Protein FON, plays a crucial role in cellular processes by mediating interactions between the R2TP/Prefoldin-like complex and U5 small nuclear ribonucleoprotein. It is essential for the assembly of key components within the U5 snRNP complex, influencing its composition and functionality.
Therapeutic significance:
Understanding the role of Zinc finger HIT domain-containing protein 2 could open doors to potential therapeutic strategies.