Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q9UI12
UPID:
VATH_HUMAN
Alternative names:
Nef-binding protein 1; Protein VMA13 homolog; V-ATPase 50/57 kDa subunits; Vacuolar proton pump subunit H; Vacuolar proton pump subunit SFD
Alternative UPACC:
Q9UI12; B3KMR0; Q6PK44; Q9H3E3; Q9Y300
Background:
V-type proton ATPase subunit H, also known as Vacuolar proton pump subunit H, plays a pivotal role in acidifying intracellular compartments and the extracellular environment in certain cell types. This protein is a crucial component of the V1 complex of vacuolar(H+)-ATPase, which is essential for ATP hydrolysis and proton translocation. Its involvement in endocytosis and endosome formation highlights its significance in cellular processes.
Therapeutic significance:
Understanding the role of V-type proton ATPase subunit H could open doors to potential therapeutic strategies.