Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
Q9UJX6
UPID:
ANC2_HUMAN
Alternative names:
Cyclosome subunit 2
Alternative UPACC:
Q9UJX6; Q5VSG1; Q96DG5; Q96GG4; Q9P2E1
Background:
Anaphase-promoting complex subunit 2, also known as Cyclosome subunit 2, plays a pivotal role in cell cycle regulation. It forms a part of the anaphase promoting complex/cyclosome (APC/C), a crucial E3 ubiquitin ligase that governs mitosis and G1 phase progression. This complex is instrumental in ubiquitination and degradation of target proteins, favoring 'Lys-11'-linked polyubiquitin chains formation, while also facilitating 'Lys-48'- and 'Lys-63'-linked chains to a lesser extent. It is key in synaptic vesicle clustering at the presynaptic membrane in neurons, driving presynaptic differentiation through NEUROD2 degradation.
Therapeutic significance:
Understanding the role of Anaphase-promoting complex subunit 2 could open doors to potential therapeutic strategies.