Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
Q9UMF0
UPID:
ICAM5_HUMAN
Alternative names:
Telencephalin
Alternative UPACC:
Q9UMF0; Q9Y6F3
Background:
Intercellular adhesion molecule 5 (ICAM-5), also known as Telencephalin, plays a pivotal role in the immune system. It serves as a ligand for LFA-1 (integrin alpha-L/beta-2), facilitating leukocyte adhesion. This process is crucial for immune response regulation and cellular signaling pathways.
Therapeutic significance:
Understanding the role of Intercellular adhesion molecule 5 could open doors to potential therapeutic strategies. Its involvement in leukocyte adhesion positions it as a key target for modulating immune responses, offering avenues for the development of treatments in immune-related disorders.