Focused On-demand Library for Pre-mRNA-processing factor 19

Focused On-demand Libraries - Reaxense Collaboration

Explore the Potential with AI-Driven Innovation

This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.

The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.

In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.

Our high-tech, dedicated method is applied to construct targeted libraries for enzymes.

Fig. 1. The sreening workflow of Receptor.AI

It includes comprehensive molecular simulations of the catalytic and allosteric binding pockets and the ensemble virtual screening accounting for their conformational mobility. In the case of designing modulators, the structural changes induced by reaction intermediates are taken into account to leverage activity and selectivity.

Key features that set our library apart include:

The Receptor.AI platform integrates extensive information about the target protein, such as historical experiments, academic research, known ligands, and structural insights, thereby increasing the likelihood of identifying highly relevant compounds.
The platform’s sophisticated molecular simulations are designed to discover potential binding sites, ensuring that our focused library is optimal for the discovery of allosteric inhibitors and binders for cryptic pockets.
With over 50 customisable AI models, verified through extensive testing in commercial drug discovery and research, Receptor.AI is efficient, reliable, and precise. These models are essential in the production of our focused libraries.
Receptor.AI not only produces focused libraries but also provides full services and solutions at every stage of preclinical drug discovery, with a success-based pricing structure that aligns our interests with the success of your project.

partner

Reaxense

upacc

Q9UMS4

UPID:

PRP19_HUMAN

Alternative names:

Nuclear matrix protein 200; PRP19/PSO4 homolog; RING-type E3 ubiquitin transferase PRP19; Senescence evasion factor

Alternative UPACC:

Q9UMS4

Background:

Pre-mRNA-processing factor 19, also known as PRP19, plays a pivotal role in cellular processes including pre-mRNA splicing, DNA repair, and the DNA damage response. As a core component of the spliceosome, PRP19 is essential for the assembly and activity of this complex, facilitating the splicing of pre-mRNA. It also functions in the ubiquitination of spliceosomal proteins, linking transcriptional machinery to spliceosomal assembly. Moreover, PRP19's involvement in DNA repair mechanisms, such as double-strand break repair and interstrand cross-link repair, underscores its critical role in maintaining genomic stability.

Therapeutic significance:

Understanding the role of Pre-mRNA-processing factor 19 could open doors to potential therapeutic strategies.