Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q9UNS1
UPID:
TIM_HUMAN
Alternative names:
-
Alternative UPACC:
Q9UNS1; B2ZAV0; O94802; Q86VM1; Q8IWH3
Background:
The Protein timeless homolog plays a pivotal role in DNA replication, genome stability, and the circadian clock. It stabilizes replication forks, influences CHEK1 phosphorylation, and is involved in DNA repair and homologous recombination repair. Additionally, it regulates the circadian clock by interacting with various proteins, ensuring the precise timing of cellular processes.
Therapeutic significance:
Given its involvement in Advanced sleep phase syndrome, familial, 4, and its crucial role in DNA repair and the circadian clock, targeting Protein timeless homolog could lead to innovative treatments for sleep disorders and enhance genomic stability in disease conditions.