Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
Our top-notch dedicated system is used to design specialised libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The method includes detailed molecular simulations of the catalytic and allosteric binding pockets, along with ensemble virtual screening that considers their conformational flexibility. In the design of modulators, structural changes induced by reaction intermediates are taken into account to enhance activity and selectivity.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q9UQ49
UPID:
NEUR3_HUMAN
Alternative names:
Ganglioside sialidasedis; Membrane sialidase; N-acetyl-alpha-neuraminidase 3
Alternative UPACC:
Q9UQ49; A8K327; Q9NQE1
Background:
Sialidase-3, also known as Ganglioside sialidase, Membrane sialidase, and N-acetyl-alpha-neuraminidase 3, is a crucial enzyme in the catabolism of glycolipids, glycoproteins, and oligosaccharides. It efficiently catalyzes the hydrolytic cleavage of terminal sialic acids, particularly impacting gangliosides such as GD1a, GM3, and GD3. This enzyme plays a pivotal role in cellular processes by modulating the ganglioside content of lipid bilayers and interacting directly with signaling receptors like EGFR, thereby influencing transmembrane signaling and receptor endocytosis.
Therapeutic significance:
Understanding the role of Sialidase-3 could open doors to potential therapeutic strategies. Its involvement in the regulation of key cellular processes, such as EGFR-mediated signaling and receptor trafficking, highlights its potential as a target in diseases where these pathways are dysregulated.