Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We utilise our cutting-edge, exclusive workflow to develop focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
This approach involves comprehensive molecular simulations of the catalytic and allosteric binding pockets and ensemble virtual screening that accounts for their conformational flexibility. In the case of designing modulators, the structural adjustments caused by reaction intermediates are considered to improve activity and selectivity.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q9Y237
UPID:
PIN4_HUMAN
Alternative names:
Parvulin-14; Parvulin-17; Peptidyl-prolyl cis-trans isomerase Pin4; Peptidyl-prolyl cis/trans isomerase EPVH; Rotamase Pin4
Alternative UPACC:
Q9Y237; A8E0G6; B3KXM0; F5H1P5; Q0D2H3; Q3MHV0; Q52M21; Q5HYW6; Q6IRW4
Background:
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4, known by alternative names such as Parvulin-14, Parvulin-17, and Rotamase Pin4, plays a crucial role in ribosome biogenesis through its involvement as a ribosomal RNA processing factor. Isoform 1 of this protein binds to tightly bent AT-rich stretches of double-stranded DNA, while Isoform 2 exhibits affinity for double-stranded DNA without specificity to structure.
Therapeutic significance:
Understanding the role of Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 could open doors to potential therapeutic strategies. Its pivotal function in ribosome biogenesis and DNA interaction suggests a foundational role in cellular processes, making it a target of interest for drug discovery efforts.