Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
Q9Y250
UPID:
LZTS1_HUMAN
Alternative names:
F37/esophageal cancer-related gene-coding leucine-zipper motif; Fez1
Alternative UPACC:
Q9Y250; D3DSQ6; Q9Y5V7; Q9Y5V8; Q9Y5V9; Q9Y5W0; Q9Y5W1; Q9Y5W2
Background:
Leucine zipper putative tumor suppressor 1 (LZTS1), also known as Fez1, plays a crucial role in cell growth regulation. It is believed to stabilize the CDC2-cyclin B1 complex, contributing to cell cycle regulation and preventing uncontrolled cell proliferation. This protein's involvement in such fundamental cellular processes underscores its potential as a key player in tumor suppression.
Therapeutic significance:
Given its association with esophageal cancer, understanding the role of Leucine zipper putative tumor suppressor 1 could open doors to potential therapeutic strategies. Its function in stabilizing cell cycle complexes suggests that targeting LZTS1 pathways may offer new avenues for cancer treatment, particularly in combating esophageal malignancies.