Focused On-demand Library for Sodium-dependent multivitamin transporter

Available from Reaxense
Predicted by Alphafold

Focused On-demand Libraries - Reaxense Collaboration

Explore the Potential with AI-Driven Innovation

Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.

We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.

Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.

We utilise our cutting-edge, exclusive workflow to develop focused libraries.

 Fig. 1. The sreening workflow of Receptor.AI

Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.

Key features that set our library apart include:

  • The Receptor.AI platform integrates extensive information about the target protein, such as historical experiments, academic research, known ligands, and structural insights, thereby increasing the likelihood of identifying highly relevant compounds.
  • The platform’s sophisticated molecular simulations are designed to discover potential binding sites, ensuring that our focused library is optimal for the discovery of allosteric inhibitors and binders for cryptic pockets.
  • With over 50 customisable AI models, verified through extensive testing in commercial drug discovery and research, Receptor.AI is efficient, reliable, and precise. These models are essential in the production of our focused libraries.
  • Receptor.AI not only produces focused libraries but also provides full services and solutions at every stage of preclinical drug discovery, with a success-based pricing structure that aligns our interests with the success of your project.







Alternative names:

Solute carrier family 5 member 6

Alternative UPACC:

Q9Y289; B2RB85; D6W549; Q969Y5


The Sodium-dependent multivitamin transporter, also known as Solute carrier family 5 member 6, plays a crucial role in the electrogenic transport of essential nutrients such as pantothenate, biotin, and lipoate across cell membranes. It operates as a Na+-coupled substrate symporter, utilizing an electrochemical Na+ gradient to facilitate substrate uptake. This protein is vital for biotin and pantothenate absorption in the intestine and contributes to the maintenance of intestinal mucosa integrity and the transport of these vitamins into the brain across the blood-brain barrier.

Therapeutic significance:

Linked to Sodium-dependent multivitamin transporter deficiency and Peripheral motor neuropathy, childhood-onset, biotin-responsive, this transporter's dysfunction highlights its therapeutic significance. Treatments with biotin, pantothenic acid, and lipoic acid show clinical improvement, underscoring the potential of targeting this transporter in therapeutic strategies.

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