Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We employ our advanced, specialised process to create targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The method includes detailed molecular simulations of the catalytic and allosteric binding pockets, along with ensemble virtual screening that considers their conformational flexibility. In the design of modulators, structural changes induced by reaction intermediates are taken into account to enhance activity and selectivity.
Key features that set our library apart include:
partner
Reaxense
upacc
Q9Y2C4
UPID:
EXOG_HUMAN
Alternative names:
Endonuclease G-like 1
Alternative UPACC:
Q9Y2C4; A8K242; B4DVG2; Q3SXM9; Q9Y2C8
Background:
Nuclease EXOG, mitochondrial, also known as Endonuclease G-like 1, plays a crucial role in cellular processes with its endo/exonuclease activities. It exhibits a preference for single-stranded DNA and demonstrates significant nicking activity towards supercoiled DNA, alongside 5'-3' exonuclease activity. This protein's unique ability to interact with DNA makes it a key player in mitochondrial DNA maintenance and repair.
Therapeutic significance:
Understanding the role of Nuclease EXOG, mitochondrial could open doors to potential therapeutic strategies. Its involvement in DNA repair mechanisms positions it as a potential target for interventions in diseases where DNA damage is a contributing factor.