Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q9Y2V7
UPID:
COG6_HUMAN
Alternative names:
Component of oligomeric Golgi complex 6
Alternative UPACC:
Q9Y2V7; Q5T0U1; Q6AI19; Q86V49; Q9ULT5
Background:
Conserved oligomeric Golgi complex subunit 6, also known as Component of oligomeric Golgi complex 6, plays a pivotal role in maintaining normal Golgi function. This protein is essential for the proper processing and sorting of proteins, ensuring they reach their correct cellular destinations. Its involvement in glycoprotein biosynthesis underscores its importance in cellular physiology and development.
Therapeutic significance:
The protein is linked to Congenital disorder of glycosylation 2L and Shaheen syndrome, diseases characterized by severe developmental and physiological anomalies. These associations highlight the protein's critical role in human health and disease, making it a potential target for therapeutic intervention. Understanding the role of Conserved oligomeric Golgi complex subunit 6 could open doors to potential therapeutic strategies.