Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q9Y496
UPID:
KIF3A_HUMAN
Alternative names:
Microtubule plus end-directed kinesin motor 3A
Alternative UPACC:
Q9Y496; A8MSW9; Q59EN1; Q86XE9; Q9Y6V4
Background:
Kinesin-like protein KIF3A, also known as Microtubule plus end-directed kinesin motor 3A, is pivotal in microtubule-based anterograde translocation of membranous organelles. It exhibits plus end-directed microtubule sliding activity in vitro, essential for primary cilia formation, centriole cohesion, and subdistal appendage organization. KIF3A's role in recruiting DCTN1 to the centriole and in ciliary basal feet formation underscores its significance in microtubule anchoring.
Therapeutic significance:
Understanding the role of Kinesin-like protein KIF3A could open doors to potential therapeutic strategies.