Focused On-demand Library for Diacylglycerol lipase-alpha

Available from Reaxense
Predicted by Alphafold

Focused On-demand Libraries - Reaxense Collaboration

Explore the Potential with AI-Driven Innovation

The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.

The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.

Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.

We utilise our cutting-edge, exclusive workflow to develop focused libraries for enzymes.

 Fig. 1. The sreening workflow of Receptor.AI

The procedure entails thorough molecular simulations of the catalytic and allosteric binding pockets, accompanied by ensemble virtual screening that factors in their conformational flexibility. When developing modulators, the structural modifications brought about by reaction intermediates are factored in to optimize activity and selectivity.

Key features that set our library apart include:

  • The Receptor.AI platform integrates extensive information about the target protein, such as historical experiments, academic research, known ligands, and structural insights, thereby increasing the likelihood of identifying highly relevant compounds.
  • The platform’s sophisticated molecular simulations are designed to discover potential binding sites, ensuring that our focused library is optimal for the discovery of allosteric inhibitors and binders for cryptic pockets.
  • With over 50 customisable AI models, verified through extensive testing in commercial drug discovery and research, Receptor.AI is efficient, reliable, and precise. These models are essential in the production of our focused libraries.
  • Receptor.AI not only produces focused libraries but also provides full services and solutions at every stage of preclinical drug discovery, with a success-based pricing structure that aligns our interests with the success of your project.







Alternative names:

Neural stem cell-derived dendrite regulator; Sn1-specific diacylglycerol lipase alpha

Alternative UPACC:

Q9Y4D2; A0A024R517; A7E233; Q6WQJ0


Diacylglycerol lipase-alpha, also known as Neural stem cell-derived dendrite regulator and Sn1-specific diacylglycerol lipase alpha, is a serine hydrolase pivotal in the biosynthesis of the endocannabinoid 2-arachidonoylglycerol (2-AG). This enzyme selectively hydrolyzes diacylglycerols containing arachidonic acid, playing a crucial role in central nervous system signaling, supporting axonal growth, and regulating neuroinflammatory responses.

Therapeutic significance:

Spinocerebellar ataxia 20 (SCA20), a disorder characterized by progressive incoordination and dysarthria, is linked to alterations in the gene encoding Diacylglycerol lipase-alpha. Understanding the role of Diacylglycerol lipase-alpha could open doors to potential therapeutic strategies for treating SCA20 and other neurodegenerative diseases.

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