Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
Our high-tech, dedicated method is applied to construct targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
This approach involves comprehensive molecular simulations of the catalytic and allosteric binding pockets and ensemble virtual screening that accounts for their conformational flexibility. In the case of designing modulators, the structural adjustments caused by reaction intermediates are considered to improve activity and selectivity.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q9Y4E8
UPID:
UBP15_HUMAN
Alternative names:
Deubiquitinating enzyme 15; Ubiquitin thioesterase 15; Ubiquitin-specific-processing protease 15; Unph-2; Unph4
Alternative UPACC:
Q9Y4E8; Q08AL5; Q9H8G9; Q9HCA6; Q9UNP0; Q9Y5B5
Background:
Ubiquitin carboxyl-terminal hydrolase 15, known by alternative names such as Deubiquitinating enzyme 15 and Ubiquitin-specific-processing protease 15, plays a pivotal role in cellular processes. It regulates pathways including TGF-beta receptor signaling, NF-kappa-B, and mitophagy by removing conjugated ubiquitin from proteins. This enzyme is crucial in modulating gene expression, DNA repair, and endosome organization through its deubiquitinating activities.
Therapeutic significance:
Understanding the role of Ubiquitin carboxyl-terminal hydrolase 15 could open doors to potential therapeutic strategies.