Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q9Y5X2
UPID:
SNX8_HUMAN
Alternative names:
-
Alternative UPACC:
Q9Y5X2; A4D207; Q96I67
Background:
Sorting nexin-8 plays a crucial role in intracellular trafficking, facilitating protein transport from early endosomes to the trans-Golgi network. This process is vital for the proper functioning of cellular components and the maintenance of cellular integrity.
Therapeutic significance:
Understanding the role of Sorting nexin-8 could open doors to potential therapeutic strategies. Its involvement in intracellular protein transport suggests its potential as a target in diseases where this process is disrupted.