Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q9Y624
UPID:
JAM1_HUMAN
Alternative names:
Junctional adhesion molecule 1; Platelet F11 receptor; Platelet adhesion molecule 1
Alternative UPACC:
Q9Y624; B7Z941
Background:
Junctional adhesion molecule A (JAM-A), also known as Platelet F11 receptor and Platelet adhesion molecule 1, plays a pivotal role in epithelial tight junction formation. It is crucial in the early stages of cell junctions, recruiting PARD3 to prevent its interaction with JAM1, thus inhibiting tight junction assembly. JAM-A is also key in monocyte transmigration, maintaining epithelial barrier integrity, and acts as a ligand for integrin alpha-L/beta-2, facilitating memory T-cell and neutrophil transmigration. Additionally, it is involved in platelet activation and serves as a receptor for pathogens like Mammalian reovirus sigma-1 and Human Rotavirus strain Wa.
Therapeutic significance:
Understanding the role of Junctional adhesion molecule A could open doors to potential therapeutic strategies, particularly in enhancing epithelial barrier function and modulating immune cell transmigration.