Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
Q9Y676
UPID:
RT18B_HUMAN
Alternative names:
28S ribosomal protein S18-2, mitochondrial; 28S ribosomal protein S18b, mitochondrial; Small ribosomal subunit protein bS18b
Alternative UPACC:
Q9Y676; A6NDQ0; Q659G4; Q9BS27
Background:
The Small ribosomal subunit protein mS40, also known as 28S ribosomal protein S18-2, mitochondrial, 28S ribosomal protein S18b, mitochondrial, and Small ribosomal subunit protein bS18b, plays a crucial role in the mitochondrial ribosome. Its primary function is to ensure the proper assembly and function of the ribosome, which is essential for protein synthesis within the cell.
Therapeutic significance:
Understanding the role of Small ribosomal subunit protein mS40 could open doors to potential therapeutic strategies. Its pivotal role in protein synthesis makes it an intriguing target for research aimed at addressing mitochondrial diseases and disorders related to protein synthesis.