Focused On-demand Library for Chloride intracellular channel protein 4

Focused On-demand Libraries - Reaxense Collaboration

Explore the Potential with AI-Driven Innovation

This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.

The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.

In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.

We utilise our cutting-edge, exclusive workflow to develop focused libraries.

Fig. 1. The sreening workflow of Receptor.AI

Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.

Our library is unique due to several crucial aspects:

Receptor.AI compiles all relevant data on the target protein, such as past experimental results, literature findings, known ligands, and structural data, thereby enhancing the likelihood of focusing on the most significant compounds.
By utilizing advanced molecular simulations, the platform is adept at locating potential binding sites, rendering the compounds in the focused library well-suited for unearthing allosteric inhibitors and binders for hidden pockets.
The platform is supported by more than 50 highly specialized AI models, all of which have been rigorously tested and validated in diverse drug discovery and research programs. Its design emphasizes efficiency, reliability, and accuracy, crucial for producing focused libraries.
Receptor.AI extends beyond just creating focused libraries; it offers a complete spectrum of services and solutions during the preclinical drug discovery phase, with a success-dependent pricing strategy that reduces risk and fosters shared success in the project.

partner

Reaxense

upacc

Q9Y696

UPID:

CLIC4_HUMAN

Alternative names:

Intracellular chloride ion channel protein p64H1

Alternative UPACC:

Q9Y696; Q9UFW9; Q9UQJ6

Background:

Chloride intracellular channel protein 4, also known as Intracellular chloride ion channel protein p64H1, plays a crucial role in various cellular processes. It can insert into membranes to form ion channels, facilitating the transport of chloride ions. This activity is pH-dependent and influenced by redox conditions, suggesting a complex regulation mechanism. The protein is also involved in promoting cell-surface expression of HRH3 and has been implicated in processes such as angiogenesis, cell proliferation, and maintaining membrane polarity during cell division.

Therapeutic significance:

Understanding the role of Chloride intracellular channel protein 4 could open doors to potential therapeutic strategies. Its involvement in critical cellular functions and processes like angiogenesis and cell proliferation highlights its potential as a target for therapeutic intervention in diseases where these processes are dysregulated.