Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We employ our advanced, specialised process to create targeted libraries for receptors.
Fig. 1. The sreening workflow of Receptor.AI
The method involves detailed molecular simulations of the receptor in its native membrane environment, with ensemble virtual screening focusing on its conformational mobility. When dealing with dimeric or oligomeric receptors, the whole functional complex is modelled, and the tentative binding pockets on and between the subunits are established to address all possible mechanisms of action.
Key features that set our library apart include:
partner
Reaxense
upacc
Q9Y6C5
UPID:
PTC2_HUMAN
Alternative names:
-
Alternative UPACC:
Q9Y6C5; O95341; O95856; Q53Z57; Q5QP87; Q6UX14
Background:
Protein patched homolog 2, encoded by the gene with accession number Q9Y6C5, is pivotal in cellular growth control and epidermal development. It is suggested to act as a receptor for Sonic hedgehog (SHH), playing a critical role in the SHH signaling pathway which is essential for embryonic development.
Therapeutic significance:
The protein is implicated in the pathogenesis of Medulloblastoma, a malignant cerebellar tumor predominantly affecting children, and Basal cell carcinoma, a common skin cancer. These associations highlight its potential as a target for therapeutic intervention in these cancers.