Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
Our high-tech, dedicated method is applied to construct targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
This approach involves comprehensive molecular simulations of the catalytic and allosteric binding pockets and ensemble virtual screening that accounts for their conformational flexibility. In the case of designing modulators, the structural adjustments caused by reaction intermediates are considered to improve activity and selectivity.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q9Y6M0
UPID:
TEST_HUMAN
Alternative names:
Eosinophil serine protease 1; Serine protease 21
Alternative UPACC:
Q9Y6M0; Q9NS34; Q9P2V6
Background:
Testisin, also known as Eosinophil serine protease 1 or Serine protease 21, plays a crucial role in the maturation of testicular germ cells. Its unique function in regulating proteolytic events highlights its importance in reproductive biology.
Therapeutic significance:
Understanding the role of Testisin could open doors to potential therapeutic strategies. Its involvement in testicular germ cell maturation presents an opportunity for targeted interventions in reproductive health.