Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
O43482
UPID:
MS18B_HUMAN
Alternative names:
Cancer/testis antigen 86; Opa-interacting protein 5
Alternative UPACC:
O43482; Q96BX7
Background:
Protein Mis18-beta, also known as Cancer/testis antigen 86 and Opa-interacting protein 5, plays a crucial role in the recruitment of CENPA to centromeres, ensuring normal chromosome segregation during mitosis. This process is vital for accurate cell division and genomic stability.
Therapeutic significance:
Understanding the role of Protein Mis18-beta could open doors to potential therapeutic strategies. Its pivotal function in chromosome segregation highlights its importance in maintaining cellular integrity and presents a unique target for drug discovery in cancer therapy.