Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
O75366
UPID:
AVIL_HUMAN
Alternative names:
p92
Alternative UPACC:
O75366; B2RAU7; Q2NKM9
Background:
Advillin, known as p92, is a Ca(2+)-regulated actin-binding protein pivotal in actin bundling. It is essential in neuronal cell morphogenesis, ganglia formation, and plays a critical role in sensory axon outgrowth and remodeling post-injury. Additionally, it is involved in fibroblast filopodia formation and ciliogenesis, and regulates lamellipodia formation in podocytes by modulating EGF-induced diacylglycerol production and ARP2/3 complex assembly.
Therapeutic significance:
Advillin's association with Nephrotic syndrome 21, a severe renal disorder marked by early-onset kidney dysfunction, highlights its therapeutic potential. Understanding the role of Advillin could open doors to potential therapeutic strategies for this steroid-resistant, rapidly progressive condition.