Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
O95398
UPID:
RPGF3_HUMAN
Alternative names:
Exchange factor directly activated by cAMP 1; Exchange protein directly activated by cAMP 1; Rap1 guanine-nucleotide-exchange factor directly activated by cAMP; cAMP-regulated guanine nucleotide exchange factor I
Alternative UPACC:
O95398; A8K2G5; E7EQC8; O95634; Q8WVN0
Background:
Rap guanine nucleotide exchange factor 3, also known as Exchange factor directly activated by cAMP 1, plays a pivotal role in cellular processes by acting as a Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases. Its activation by cAMP leads to the assembly of a signaling complex that activates the PI3K gamma complex, crucial for angiogenesis. This protein is instrumental in modulating cAMP-induced endothelial barrier function and is essential for actin rearrangement at cell-cell junctions.
Therapeutic significance:
Understanding the role of Rap guanine nucleotide exchange factor 3 could open doors to potential therapeutic strategies.