Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We utilise our cutting-edge, exclusive workflow to develop focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The method includes detailed molecular simulations of the catalytic and allosteric binding pockets, along with ensemble virtual screening that considers their conformational flexibility. In the design of modulators, structural changes induced by reaction intermediates are taken into account to enhance activity and selectivity.
Key features that set our library apart include:
partner
Reaxense
upacc
O95620
UPID:
DUS4L_HUMAN
Alternative names:
pp35; tRNA-dihydrouridine synthase 4-like
Alternative UPACC:
O95620; B4DLX0; Q2NKK1
Background:
The tRNA-dihydrouridine(20a/20b) synthase [NAD(P)+]-like, also known as pp35 and tRNA-dihydrouridine synthase 4-like, plays a crucial role in the post-transcriptional modification of tRNA. It catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs, which is essential for the proper folding and function of tRNA molecules.
Therapeutic significance:
Understanding the role of tRNA-dihydrouridine(20a/20b) synthase [NAD(P)+]-like could open doors to potential therapeutic strategies. Its involvement in the fundamental process of protein synthesis positions it as a key target for drug discovery, aiming to modulate protein production in various diseases.