Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
P07316
UPID:
CRGB_HUMAN
Alternative names:
Gamma-B-crystallin; Gamma-crystallin 1-2
Alternative UPACC:
P07316; Q17RB5; Q53ST2
Background:
Gamma-crystallin B, also known as Gamma-B-crystallin or Gamma-crystallin 1-2, plays a pivotal role in the vertebrate eye lens, serving as a dominant structural component. This protein's unique structure and function are crucial for maintaining lens transparency and refractive power, essential for clear vision.
Therapeutic significance:
The association of Gamma-crystallin B with Cataract 39, multiple types, underscores its clinical importance. Understanding the role of Gamma-crystallin B could open doors to potential therapeutic strategies for cataract prevention and treatment, aiming to preserve or restore vision.